[HTML][HTML] Coping with stress: how bacteria fine-tune protein synthesis and protein transport
Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin–antitoxin and related phage defense systems
Toxin-antitoxin (TA) systems are a large group of small genetic modules found in
prokaryotes and their mobile genetic elements. Type II TAs are encoded as bicistronic (two …
prokaryotes and their mobile genetic elements. Type II TAs are encoded as bicistronic (two …
Breaking bad nucleotides: understanding the regulatory mechanisms of bacterial small alarmone hydrolases
A Chrenková, F Bisiak, DE Brodersen - Trends in Microbiology, 2024 - cell.com
Guanosine tetra-and pentaphosphate nucleotides,(p) ppGpp, function as central secondary
messengers and alarmones in bacterial cell biology, signalling a range of stress conditions …
messengers and alarmones in bacterial cell biology, signalling a range of stress conditions …
The structure of DarB in complex with RelNTD reveals nonribosomal activation of Rel stringent factors
Rel stringent factors are bifunctional ribosome-associated enzymes that catalyze both
synthesis and hydrolysis of the alarmones (p) ppGpp. Besides the allosteric control by …
synthesis and hydrolysis of the alarmones (p) ppGpp. Besides the allosteric control by …
Mechanisms of neutralization of toxSAS from toxin–antitoxin modules
L Dominguez-Molina, T Kurata, A Cepauskas… - Nature Chemical …, 2024 - nature.com
Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors
present in toxin–antitoxin and secretion systems. toxSASs act through either translation …
present in toxin–antitoxin and secretion systems. toxSASs act through either translation …
[HTML][HTML] A binuclear metallohydrolase model for RelA/SpoT-Homolog (RSH) hydrolases
RW Zhou, B Manisa, B Wang - Journal of Biological Chemistry, 2024 - Elsevier
When challenged by starvation, bacterial organisms synthesize guanosine pentaphosphate
and tetraphosphate, collectively denoted as (p) ppGpp, as second messengers to reprogram …
and tetraphosphate, collectively denoted as (p) ppGpp, as second messengers to reprogram …
[PDF][PDF] Biochemical and X-ray analyses of the players involved in the faRel2/aTfaRel2 toxin–antitoxin operon
L Dominguez-Molina, A Talavera… - … Section F: Structural …, 2023 - journals.iucr.org
The aTfaRel2/faRel2 operon from Coprobacillus sp. D7 encodes a bicistronic type II toxin–
antitoxin (TA) module. The FaRel2 toxin is a toxic small alarmone synthetase (toxSAS) that …
antitoxin (TA) module. The FaRel2 toxin is a toxic small alarmone synthetase (toxSAS) that …
[HTML][HTML] Synthetase and Hydrolase Specificity Collectively Excludes 2'-Deoxyguanosine from Bacterial Alarmone
RW Zhou, IJ Gordon, Y Hei, B Wang - bioRxiv, 2024 - ncbi.nlm.nih.gov
In response to starvation, virtually all bacteria pyrophosphorylate the 3'-hydroxy group of
GTP or GDP to produce two messenger nucleotides collectively denoted as (p) ppGpp. Also …
GTP or GDP to produce two messenger nucleotides collectively denoted as (p) ppGpp. Also …
Coupling between substrate specificity and neutralisation mechanisms in toxic Small Alarmone Synthetases
A Garcia-Pino, L Dominguez-Molina, T Kurata… - 2023 - researchsquare.com
Abstract Toxic Small Alarmone Synthetase (toxSAS) enzymes constitute a family of bacterial
effectors present in toxin-antitoxin (TA) and secretion systems. toxSASs act either through …
effectors present in toxin-antitoxin (TA) and secretion systems. toxSASs act either through …
[PDF][PDF] Design and synthesis of novel bisubstrate analogues of ppGpp containing diphosphate isosteres as potential RSH enzyme inhibitors
P Fouka - 2023 - scholar.archive.org
The status quo of modern antibiotics comprises of an ever growing emergence of resistance
against them and an ever shrinking discovery of new classes of antibiotic drugs …
against them and an ever shrinking discovery of new classes of antibiotic drugs …