Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer
subtype. Over the last decade, significant progress has been made in identifying the genetic …

Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

It is becoming increasingly evident that most cell types are capable of forming and releasing
multiple distinct classes of membrane-enclosed packages, referred to as extracellular …

Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most
robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins …

Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

The epithelial–mesenchymal transition (EMT) is a developmental process that is important
for embryogenesis, wound healing, organ fibrosis, and cancer metastasis. Cancer …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Distant metastasis is the main cause of breast cancer-related death; however, effective
therapeutic strategies targeting metastasis are still scarce. This is largely attributable to the …