Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity

H Hirao, K Nakamura… - … reviews Gastroenterology & …, 2022 - nature.com
Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms

WA Dar, E Sullivan, JS Bynon, H Eltzschig… - Liver …, 2019 - Wiley Online Library
Liver disease causing end organ failure is a growing cause of mortality. In most cases, the
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …

[PDF][PDF] Normothermic machine perfusion (NMP) inhibits proinflammatory responses in the liver and promotes regeneration

W Jassem, E Xystrakis, YG Ghnewa, M Yuksel… - …, 2019 - Wiley Online Library
Liver transplantation (LT) is a successful treatment for patients with liver failure. However,
organ shortage results in over 11% of patients losing their chance of a transplant attributed …

Liver transplant outcomes after ex vivo machine perfusion: a meta-analysis

B Liew, D Nasralla, S Iype, JM Pollok… - British Journal of …, 2021 - academic.oup.com
Background The pressure on liver-transplant programmes has expanded the usage of
extended-criteria allografts. Machine perfusion may be better than conventional static cold …

[HTML][HTML] The role of ischemia-reperfusion injury and liver regeneration in hepatic tumor recurrence

M Maspero, S Yilmaz, B Cazzaniga, R Raj, K Ali… - JHEP Reports, 2023 - Elsevier
The risk of cancer recurrence after liver surgery mainly depends on tumor biology, but
preclinical and clinical evidence suggests that the degree of perioperative liver injury plays a …

[PDF][PDF] Onset of donor warm ischemia time in donation after circulatory death liver transplantation: hypotension or hypoxia?

M Kalisvaart, JE de Haan, WG Polak… - Liver …, 2018 - Wiley Online Library
The aim of this study was to investigate the impact of hypoxia and hypotension during the
agonal phase of donor warm ischemia time (DWIT) on hepatic ischemia/reperfusion injury …

Ischemic-free liver transplantation reduces the recurrence of hepatocellular carcinoma after liver transplantation

Y Tang, T Wang, W Ju, F Li, Q Zhang, Z Chen… - Frontiers in …, 2021 - frontiersin.org
Ischemia reperfusion injury (IRI) is an adverse factor for hepatocellular carcinoma (HCC)
recurrence after liver transplantation. Ischemic-free liver transplantation (IFLT) is a novel …

Normothermic regional perfusion in liver transplantation from donation after cardiocirculatory death: Technical, biochemical, and regulatory aspects and review of …

F Melandro, G Basta, F Torri, G Biancofiore… - Artificial …, 2022 - Wiley Online Library
Background Organs from donation after circulatory death (DCD) are increasingly used for
liver transplantation, due to the persisting organ shortage and waiting list mortality. However …

[HTML][HTML] The AKI Prediction Score: a new prediction model for acute kidney injury after liver transplantation

M Kalisvaart, A Schlegel, I Umbro, JE de Haan… - HPB, 2019 - Elsevier
Background Acute kidney injury (AKI) is a frequent complication after liver transplantation.
Although numerous risk factors for AKI have been identified, their cumulative impact remains …

Micro‐vesicles derived from human Wharton's Jelly mesenchymal stromal cells mitigate renal ischemia‐reperfusion injury in rats after cardiac death renal …

X Wu, T Yan, Z Wang, X Wu, G Cao… - Journal of Cellular …, 2018 - Wiley Online Library
The purpose of the present study was to investigate the possible therapeutic effects of the
human Wharton‐Jelly mesenchymal stromal cells derived micro‐vesicles (hWJMSCs‐MVs) …