The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Trends in micro‐/nanorobotics: materials development, actuation, localization, and system integration for biomedical applications

B Wang, K Kostarelos, BJ Nelson… - Advanced Materials, 2021 - Wiley Online Library
Abstract Micro‐/nanorobots (m‐bots) have attracted significant interest due to their suitability
for applications in biomedical engineering and environmental remediation. Particularly, their …

Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

J Zhang, C Ji, H Zhang, H Shi, F Mao, H Qian, W Xu… - Science …, 2022 - science.org
Neutrophils are the most abundant innate immune cells in human circulation; however, their
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …

Dual-responsive biohybrid neutrobots for active target delivery

H Zhang, Z Li, C Gao, X Fan, Y Pang, T Li, Z Wu… - Science Robotics, 2021 - science.org
Swimming biohybrid microsized robots (eg, bacteria-or sperm-driven microrobots) with self-
propelling and navigating capabilities have become an exciting field of research, thanks to …

Engineering microrobots for targeted cancer therapies from a medical perspective

CK Schmidt, M Medina-Sánchez… - Nature …, 2020 - nature.com
Systemic chemotherapy remains the backbone of many cancer treatments. Due to its
untargeted nature and the severe side effects it can cause, numerous nanomedicine …

Recent progress in targeted delivery vectors based on biomimetic nanoparticles

L Chen, W Hong, W Ren, T Xu, Z Qian… - Signal transduction and …, 2021 - nature.com
Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs)
since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological …

[HTML][HTML] Neutrophil-erythrocyte hybrid membrane-coated hollow copper sulfide nanoparticles for targeted and photothermal/anti-inflammatory therapy of osteoarthritis

X Xue, H Liu, S Wang, Y Hu, B Huang, M Li… - Composites Part B …, 2022 - Elsevier
Osteoarthritis (OA), as a chronic degenerative joint disorder, has seriously affected the life
quality of patients. Despite lots of drug treatment strategies that have been studied, the …

Exploiting innate immunity for cancer immunotherapy

M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma

C Gao, Q Wang, J Li, CHT Kwong, J Wei, B Xie… - Science …, 2022 - science.org
Cell-based drug carriers are mostly prepared in vitro, which may negatively affect the
physiological functions of cells, and induce possible immune rejections when applied to …

Advances in nanomaterial-based targeted drug delivery systems

X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …