The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) is a brain
area subject to many theories and debates over its function (s). Even its precise anatomical …

Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …

Introduction Pain is often neglected in Parkinson's disease (PD), although it impacts most
PD patients. While the mechanism of pain in PD is still being studied, various …

Limitations in chronic pain therapies necessitate novel interventions that are effective,
accessible, and safe. Brain–computer interfaces (BCIs) provide a promising modality for …

Background Chronic pain of different aetiologies and localization has been associated with
less grey matter volume (GMV) in several cortical and subcortical brain areas. Recent meta …

Precision neuromodulation of central brain circuits is a promising emerging therapeutic
modality for a variety of neuropsychiatric disorders. Reliably identifying in whom, where, and …

Pain is highly subjective, so it is always desirable to develop objective pain assessment
methods. Brain imaging techniques, such as functional magnetic resonance imaging (fMRI) …

The decades since the inauguration of the International Association for the Study of Pain
have witnessed major advances in scientific concepts (such as the biopsychosocial model …

The directional organization of multiple nociceptive regions, particularly within obscure
operculoinsular areas, underlying multidimensional pain processing remains elusive. This …

Detecting and responding to threat engages several neural nodes including the amygdala,
hippocampus, insular cortex, and medial prefrontal cortices. Recent propositions call for the …