Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …

Due to the low autofluorescence and deep-photo penetration, the second near-infrared
region fluorescence imaging technology (NIR-II, 1000–2000 nm) has been widely utilized in …

Background During normal human kidney development, nephrogenesis (the formation of
nephrons) is complete by term birth, with the majority of nephrons formed late in gestation …

Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects
derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the …

Background RNA profiling technologies at single-cell resolutions, including single-cell and
single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can …

Low nephron number—resulting, for example, from prematurity or developmental anomalies—
is a risk factor for the development of hypertension, chronic kidney disease and kidney …

The mechanisms underlying kidney development in mice and humans is an area of intense
study. Insights into kidney organogenesis have the potential to guide our understanding of …

Podocyte and glomerular research is center stage for the development of improved
preventive and therapeutic strategies for chronic progressive kidney diseases. Held April 3 …

Nephron progenitors in the embryonic kidney propagate while generating differentiated
nephrons. However, in mice, the progenitors terminally differentiate shortly after birth. Here …

Background Previous research has elucidated the signals required to induce nephron
progenitor cells (NPCs) from pluripotent stem cells (PSCs), enabling the generation of …