The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …

Mannich bases are the end products of Mannich reaction and are known as beta‐amino
ketone carrying compounds. Mannich reaction is a carbon‐carbon bond forming …

Isatin, its 5-chloro and 5-bromo derivatives have been reacted with N-[4-(4′-chlorophenyl)
thiazol-2-yl] thiosemicarbazide to form Schiff bases and the N-Mannich bases of these …

A series of 2, 4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from
triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted …

Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have
appeared as a promising approach for pharmacological intervention in a variety of disorders …

Isatin (Indole 2, 3-dione), its 5-chloro and 5-bromo derivatives were added to 3-amino-2-
methylmercapto quinazolin-4 (3H)-one to form Schiff bases and the N-Mannich bases of …

In the polyol pathway, aldose reductase (AR) catalyzes the formation of sorbitol from
glucose. In order to detoxify some dangerous aldehydes, AR is essential. However, due to …

Various Mannich bases of chalcones and related compounds displayed significant
cytotoxicity toward murine P388 and L1210 leukemia cells as well as a number of human …

Abstract New mono Mannich bases,(2-(4-hydroxy-3-((4-substituephenylpiperazin-1-yl)
methyl) benzylidene)-2, 3-dihydro-1H-inden-1-one), were prepared to evaluate their …

Various 2-arylideneindanones 1, 2-arylidenetetralones 2, and 2-arylidenebenzosuberones
3 were synthesized with the aim of determining the relative orientations of the two aryl rings …