Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

BACKGROUND AND METHODS: We have reviewed and pooled data from published
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …

QuPath is new bioimage analysis software designed to meet the growing need for a user-
friendly, extensible, open-source solution for digital pathology and whole slide image …

Multicellular 3D culture and interaction with stromal components are considered essential
elements in establishing a 'more clinically relevant'tumor model. Matrix-embedded 3D …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

The tumor-stroma ratio (TSR) has been reported as a strong, independent prognostic
parameter in colon cancer as well as in other epithelial cancer types, and may be …

Purpose: Cancer-associated fibroblasts (CAF) are a major component of the colorectal
cancer tumor microenvironment. CAFs play an important role in tumor progression and …

The interaction between epithelial cancer cells and cancer-associated fibroblasts (CAFs)
has a major role in cancer progression and eventually in metastasis. In colorectal cancer …

Background The intra-tumor stroma percentage in colon cancer (CC) patients has previously
been reported by our group as a strong independent prognostic parameter. Patients with a …

Tumor-related stroma plays an active role in tumor invasion and metastasis. The tumor–
stroma ratio (TSR) in the pathologic specimen has drawn increasing attention from the field …