Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Protein therapeutics hold a prominent and rapidly expanding place among medicinal
products. Purified blood products, recombinant cytokines, growth factors, enzyme …

BACKGROUND & AIMS: The phenotypic and functional characteristics of natural killer (NK)
cells in chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are …

Analysis of protein phosphorylation with flow cytometric techniques has emerged as a
powerful tool in the field of immunological signaling, allowing cellular subsets in complex …

Flow cytometry and cell sorting are well-established technologies in clinical diagnostics and
biomedical research. Heterogeneous mixtures of cells are placed in suspension and passed …

Background. Uraemic pruritus (UP) is still one of the most vexing and disabling symptoms in
chronic renal failure. The pathogenesis of UP is obscure and effective therapeutic strategies …

Both T-helper 17 cells (Th17) and CD4+ CD25+ regulatory T cells (Treg) play important
roles in the pathogenesis of psoriasis. However, the relationship between Th17 and Treg …

The integrin α4β7 binds to MAdCAM‐1 and contributes to homing of lymphocytes to gut and
other mucosal tissues. In humans, the α4β7hi subset of circulating memory cellsappears to …

The essential role of Toll-like receptors (TLR) in innate immune responses to bacterial
pathogens is increasingly recognized, but very little is known about the role of TLRs in host …

There is a large and increasing number of therapeutic proteins approved for clinical use and
many more undergoing preclinical studies and clinical trials in humans. Most of them are …