Hemolysis, which occurs in many disease states, can trigger a diverse pathophysiologic
cascade that is related to the specific biochemical activities of free Hb and its porphyrin …

Sterile inflammation occurs in acute conditions, such as ischemia reperfusion injury and
crystal-induced arthritis, as well as with chronic diseases, such as particle-induced lung …

Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

Abstract Significance: Haptoglobin (Hp) is an abundant human plasma protein that tightly
captures hemoglobin (Hb) during hemolysis. The Hb-Hp complex formation reduces the …

Graft inflammation impairs the induction of solid organ transplant tolerance and enhances
acute and chronic rejection. Elucidating the mechanisms by which inflammation is induced …

Investigations over the past two decades are revealing complexities in the regulation of the
innate immune response, and how this response, in turn, controls adaptive immunity …

Locoregional failure (LRF) in patients with breast cancer post-surgery and post-irradiation is
linked to a dismal prognosis. In a refined new model, we identified ectonucleotide …

Solid organ transplantation is a vital therapy for end stage diseases. Decades of research
have established that components of the adaptive immune system are critical for transplant …

Abstract Ischemia/reperfusion injury (IRI), an inherent component of transplantation, affects
organ quality and transplant outcomes. Although the complexity of the pathophysiology is …

Muscle regeneration, characterized by the activation and proliferation of satellite cells and
other precursors, is accompanied by an inflammatory response and the remodeling of the …