Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

I Jurado-Martín, M Sainz-Mejías… - International journal of …, 2021 - mdpi.com
Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions Between Pseudomonas aeruginosa and Staphylococcus aureus

L Camus, P Briaud, F Vandenesch… - Frontiers in …, 2021 - frontiersin.org
Pseudomonas aeruginosa and Staphylococcus aureus are the two most prevalent bacteria
species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical …

[HTML][HTML] Unraveling antimicrobial resistance using metabolomics

M Kok, L Maton, M van der Peet, T Hankemeier… - Drug Discovery …, 2022 - Elsevier
The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …

Evolution of antibiotic tolerance shapes resistance development in chronic Pseudomonas aeruginosa infections

I Santi, P Manfredi, E Maffei, A Egli, U Jenal - MBio, 2021 - Am Soc Microbiol
The widespread use of antibiotics promotes the evolution and dissemination of resistance
and tolerance mechanisms. To assess the relevance of tolerance and its implications for …

Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis

R La Rosa, E Rossi, AM Feist, HK Johansen… - Nature …, 2021 - nature.com
Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa
is often accompanied by a reduction in bacterial growth rate. This reduction has been …

Biochemistry, genetics and biotechnology of glycerol utilization in Pseudomonas species

I Poblete‐Castro, C Wittmann… - Microbial …, 2020 - Wiley Online Library
The use of renewable waste feedstocks is an environment‐friendly choice contributing to the
reduction of waste treatment costs and increasing the economic value of industrial by …

From genotype to phenotype: adaptations of Pseudomonas aeruginosa to the cystic fibrosis environment

L Camus, F Vandenesch, K Moreau - Microbial genomics, 2021 - microbiologyresearch.org
Pseudomonas aeruginosa is one of the main microbial species colonizing the lungs of cystic
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …

Contextual flexibility in Pseudomonas aeruginosa central carbon metabolism during growth in single carbon sources

SK Dolan, M Kohlstedt, S Trigg, P Vallejo Ramirez… - MBio, 2020 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic human pathogen, particularly noted for
causing infections in the lungs of people with cystic fibrosis (CF). Previous studies have …

Within-host evolution of bacterial pathogens in acute and chronic infection

JP Dekker - Annual Review of Pathology: Mechanisms of …, 2024 - annualreviews.org
Bacterial pathogens undergo remarkable adaptive change in response to the selective
forces they encounter during host colonization and infection. Studies performed over the …