The improved survival outcomes of patients with non-small-cell lung cancer (NSCLC),
largely owing to the improved control of systemic disease provided by immune-checkpoint …

The long-term use of prescription and over-the-counter drugs can induce subclinical and
clinically relevant micronutrient deficiencies, which may develop gradually over months or …

Purpose Predicting target site drug concentration in the brain is of key importance for the
successful development of drugs acting on the central nervous system. We propose a …

Worldwide use of organophosphate pesticides as agricultural chemicals aims to maintain a
stable food supply, while their toxicity remains a major public health concern. A common …

Abstract Purpose: AZD1775, a first-in-class, small-molecule inhibitor of the Wee1 tyrosine
kinase, is under evaluation as a potential chemo-and radiosensitizer for treating …

Background Many studies have focused on the challenges of small molecule uptake across
the blood–brain barrier, whereas few in-depth studies have assessed the challenges with …

Drug development for the central nervous system (CNS) is a complex endeavour with low
success rates, as the structural complexity of the brain and specifically the blood-brain …

Despite the enormous research efforts that have been put into the development of central
nervous system (CNS) drugs, the success rate in this area is still disappointing. To increase …

Antibiotic excretion into milk depends on several factors such as the compound's
physicochemical properties, the animal physiology, and the milk composition. The objective …

Introduction The unbound brain extracelullar fluid (brainECF) to plasma steady state
partition coefficient, Kp, uu, BBB, values provide steady-state information on the extent of …