Most of the newly developed drug candidates are lipophilic and poorly water-soluble.
Enhancing the dissolution and bioavailability of these drugs is a major challenge for the …

Importance of the field: Most of the drugs that have been invented are of BCS Class II.
Therefore, dissolution rate enhancement is the key aspect for absorption of these drugs …

In this study, gliclazide-loaded cubosomal particles were prepared for improving the oral
bioavailability and antidiabetic activity of gliclazide. Four formulations of gliclazide-loaded …

Liquisolid system is a novel concept of drug delivery via oral route. This technique is applied
to water insoluble drugs and lipophilic drugs to sustain their release. Formulation and …

Solubility of poorly water‐soluble drugs is one of the most emerging issue associated with
these drugs to form a suitable dosage form that will provide desired pharmacological …

Pioglitazone, a class II Biopharmaceutical Classification System drug having poor water
solubility and slow dissolution rate may have a negative impact on its subtherapeutic plasma …

Solubility is concerned with solute and solvent to form a homogenous mixture. If solubility of
a drug is low, then usually it is difficult to achieve desired therapeutic level of drug. Most of …

The gold (III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS, kS′)-N-
methylglycinate] gold (III)), is endowed with promising in vitro/in vivo antitumor activity and …

Because of poor solubility and considerable metabolism, vardenafil (VRD) bioavailability is
15%. To overcome this obstacle, this study aimed to increase the solubility, hasten the onset …

Background The present research was aimed to develop a self-microemulsifying drug
delivery system (SMEDDS) pellet to increase the dissolution rate and in vivo hypoglycemic …