Spermatogenesis is a developmental process during which a small number of diploid
spermatogonial stem cells produce a large number of highly differentiated spermatozoa …

Adult tissue-specific stem cells have the capacity to self-renew and generate functional
differentiated cells that replenish lost cells throughout an organism's lifetime. Studies on …

The concept that stem cells are controlled by particular microenvironments known as' niches'
has been widely invoked. But niches have remained largely a theoretical construct because …

Stem cells are rare cells that are uniquely capable of both reproducing themselves (self-
renewing) and generating the differentiated cell types that are needed to carry out …

Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and
sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing …

Stem cell niches are dynamic microenvironments that balance stem cell activity to maintain
tissue homeostasis and repair throughout the lifetime of an organism. The development of …

Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic
stem cell activity. Somatic stem cells have to respond to tissue damage and proliferate …

One of the key characteristics of stem cells is their capacity to divide for long periods of time
in an environment where most of the cells are quiescent. Therefore, a critical question in …

The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues
from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling …

Asymmetric division of adult stem cells generates one self-renewing stem cell and one
differentiating cell, thereby maintaining tissue homeostasis. A decline in stem cell function …