Many bacterial and archaeal organisms use clustered regularly interspaced short
palindromic repeats–CRISPR associated (CRISPR–Cas) systems to defend themselves …

Bacterial and archaeal CRISPR-Cas systems offer adaptive immune protection against
foreign mobile genetic elements (MGEs). This function is regulated by sequence specific …

Robust and precise transcript targeting in mammalian cells remains a difficult challenge
using existing approaches due to inefficiency, imprecision and subcellular …

CRISPR-Cas systems employ ribonucleoprotein complexes to identify nucleic acid targets
with complementarity to bound CRISPR RNAs. Analyses of the high diversification of these …

Despite a wide presence of type III clustered regularly interspaced short palindromic
repeats, CRISPR-associated (CRISPR-Cas) in archaea and bacteria, very few anti-CRISPR …

As a phenotypically and phylogenetically diverse group, lactic acid bacteria are found in a
variety of natural environments and occupy important roles in medicine, biotechnology, food …

Abstract The type III CRISPR–Cas systems provide immunity against invading nucleic acids
through the coordinated transcription-dependent DNA targeting and cyclic adenylate (cA n) …

Abstract The type III CRISPR-Cas effector complex Csm functions as a molecular Swiss
army knife that provides multilevel defense against foreign nucleic acids. The coordinated …

Genome editing technologies that are currently available and described have a fundamental
impact on the development of molecular biology and medicine, industrial and agricultural …

The small RNA-mediated immunity in bacteria depends on foreign RNA-activated and self
RNA-inhibited enzymatic activities. The multi-subunit Type III-A CRISPR-Cas effector …