Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from
the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to …

Combined pituitary hormone deficiency (CPHD) has been linked with rare abnormalities in
genes encoding transcription factors necessary for pituitary development 1. We have …

The Aristaless‐related homeobox gene (ARX) is one of the most frequently mutated genes
in a spectrum of X‐chromosome phenotypes with intellectual disability (ID) as their cardinal …

CSX/NKX2. 5 is an evolutionarily conserved homeodomain-containing (HD-containing)
transcription factor that is essential for early cardiac development. Recently, ten different …

The application of the powerful tool molecular biology has made it possible to ask questions
not only about hormone production and action but also to characterize many of the receptor …

The Prophet of Pit-1 gene (PROP1) encodes a paired-like homeodomain protein, which is
expressed early in pituitary gland development. When mutated, it is responsible for …

Alterations of the gene encoding the pituitary transcription factor PROP1 were associated
with congenital forms of multiple pituitary hormone deficiencies in several families. Among …

The somatotropic axis is the central postnatal regulator of longitudinal growth. One of its
major components–growth hormone–is produced by the anterior lobe of the pituitary, which …

Objective Combined pituitary hormonal deficiency (CPHD) can result from mutations within
genes that encode transcription factors. This study evaluated the frequency of mutations in …