Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable
chromatin modifications. There has been considerable interest in whether environmental …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …

Abstract Sirtuin 1 (Sirt1), a NAD+-regulated deacetylase with numerous known positive
effects on cellular and whole-body metabolism, is expressed in the renal cortex and …

Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

Aging of organisms begins from a single cell at the molecular level. It includes changes
related to telomere shortening, cell senescence and epigenetic modifications. These …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

The ovary is the first organ to age in humans with functional decline evident already in
women in their early 30s. Reproductive aging is characterized by a decrease in oocyte …

Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …