Intracellular transport is fundamental for cellular function, survival and morphogenesis.
Kinesin superfamily proteins (also known as KIFs) are important molecular motors that …

The large size and extreme polarization of neurons is crucial to their ability to communicate
at long distances and to form the complex cellular networks of the nervous system. The size …

We have isolated a human homolog of Xenopus Eg5, a kinesin-related motor protein
implicated in the assembly and dynamics of the mitotic spindle. We report that microinjection …

Although small molecules such as ATP diffuse freely in the cytosol, many types of cells
nonetheless position their mitochondria in regions of intense ATP consumption. We …

The cargo that the molecular motor kinesin moves along microtubules has been elusive. We
searched for binding partners of the COOH terminus of kinesin light chain, which contains …

Membrane‐bounded organelles (MBOs) are delivered to different domains in neurons by
fast axonal transport. The importance of kinesin for fast antero grade transport is well …

The mammalian central nervous system (CNS) requires the proper formation of exquisitely
precise circuits to function correctly. These neuronal circuits are assembled during …

When not bound to cargo, the motor protein kinesin is in an inhibited state that has low
microtubule-stimulated ATPase activity. Inhibition serves to minimize the dissipation of ATP …

Conventional kinesin transports membranes along microtubules in vivo, but the majority of
cellular kinesin is unattached to cargo. The motility of non-cargo-bound, soluble kinesin may …

Neuronal transmission of information requires polarized distribution of membrane proteins
within axonal compartments. Membrane proteins are synthesized and packaged in …