Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …

Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …

Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …

Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource
remains an invaluable source of information for the study of motif-mediated protein-protein …

Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …

Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …

Nuclear processes such as DNA replication, transcription, and RNA processing each
depend on the concerted action of many different protein and RNA molecules. How …

Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …