Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …

Background: The incidence of glycolipid metabolic diseases is extremely high worldwide,
which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress …

The cerebral ischemia injury can result in neuronal death and/or functional impairment,
which leads to further damage and dysfunction after recovery of blood supply. Cerebral …

Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been
implicated with human life since ancient time, far earlier than their isolation and identification …

The transcription factor, nuclear factor E2‐related factor 2 (Nrf2), is highly sensitive to
oxidative burst products, including reactive oxygen species (ROS) and reactive nitrogen …

Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Endometrial carcinoma (EC) has become one of the most common gynecological malignant
neoplasms in developed countries worldwide. Studies have shown that this may be closely …

Among the world's leading causes of cardiovascular disease, atherosclerosis is a chronic
inflammatory disorder that affects the arteries. Both vasodilation and vasoconstriction, low …

Objective—Atherosclerosis is a chronic multifactorial and inflammatory disease of large and
medium arteries and the leading cause of cardiovascular diseases worldwide. The aim of …

Abstract Alkannin/shikonin (A/S) and their derivatives are naturally occurring
naphthoquinones majorly found in Boraginaceae family plants. They are integral …