[HTML][HTML] An epigenetic barrier sets the timing of human neuronal maturation
The pace of human brain development is highly protracted compared with most other
species,,,,,–. The maturation of cortical neurons is particularly slow, taking months to years to …
species,,,,,–. The maturation of cortical neurons is particularly slow, taking months to years to …
Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model …
S Aktar, F Ferdousi, S Kondo, T Kagawa, H Isoda - GeroScience, 2024 - Springer
In recent years, exploring natural compounds with functional properties to ameliorate aging-
associated cognitive decline has become a research priority to ensure healthy aging. In the …
associated cognitive decline has become a research priority to ensure healthy aging. In the …
Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats
C Yang, C Zheng, Y Zhuang, S Xu, J Li, C Hu - Molecular Neurobiology, 2024 - Springer
Synaptic dysfunction is considered the best neuropathological correlate of cognitive decline
in vascular dementia (VaD). However, the alterations of synaptic proteins at the …
in vascular dementia (VaD). However, the alterations of synaptic proteins at the …
Human iPSC-derived neurons with reliable synapses and large presynaptic action potentials
Understanding the function of the human brain requires determining basic properties of
synaptic transmission in human neurons. One of the most fundamental parameters …
synaptic transmission in human neurons. One of the most fundamental parameters …
Stearoyl CoA desaturase inhibition can effectively induce apoptosis in bladder cancer stem cells
Y Li, C Piao, C Kong - Cancer Cell International, 2024 - Springer
Bladder cancer stands as one of the most prevalent cancers worldwide. While our previous
research confirmed the significant role of stearoyl-CoA desaturase (SCD) in bladder cancer …
research confirmed the significant role of stearoyl-CoA desaturase (SCD) in bladder cancer …
The effect of P2X7 antagonism on subcortical spread of optogenetically-triggered cortical spreading depression and neuroinflammation
Migraine is a neurological disorder characterized by episodes of severe headache. Cortical
spreading depression (CSD), the electrophysiological equivalent of migraine aura, results in …
spreading depression (CSD), the electrophysiological equivalent of migraine aura, results in …
[HTML][HTML] CRISPR-Cas9 editing of synaptic genes in human embryonic stem cells for functional analysis in induced human neurons
Generating stable human embryonic stem cells (hESCs) with targeted genetic mutations
allows for the interrogation of protein function in numerous cellular contexts while …
allows for the interrogation of protein function in numerous cellular contexts while …
Genetic disorders of neurotransmitter release machinery
B Uzay, ET Kavalali - Frontiers in Synaptic Neuroscience, 2023 - frontiersin.org
Synaptic neurotransmitter release is an evolutionarily conserved process that mediates
rapid information transfer between neurons as well as several peripheral tissues. Release of …
rapid information transfer between neurons as well as several peripheral tissues. Release of …