In this review, we explore different approaches for introducing bioactivity into poly (ethylene
glycol)(PEG) hydrogels. Hydrogels are excellent scaffolding materials for repairing and …

One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …

As materials technology and the field of biomedical engineering advances, the role of
cellular mechanisms, in particular adhesive interactions with implantable devices, becomes …

With advancements in biological and engineering sciences, the definition of an ideal
biomaterial has evolved over the past 50 years from a substance that is inert to one that has …

Hyaluronan is a multifunctional glycosaminoglycan that forms the structural basis of the
pericellular matrix. Hyaluronan is extruded directly through the plasma membrane by one of …

The role of cancer-associated fibroblasts (CAFs) as regulators of tumor progression,
specifically vascular growth, has only recently been described. CAFs are thought to be more …

Cell adhesion occurs when integrin recognizes and binds to Arg–Gly–Asp (RGD) ligands
present in fibronectin. In this work, submolecular ligand size and spacing are tuned via …

We have characterized early steps of α2β1 integrin-mediated cell adhesion to a collagen
type I matrix by using single-cell force spectroscopy. In agreement with the role of α2β1 as a …

Background Astaxanthin (AST) is known as a powerful antioxidant that affects the removal of
active oxygen and inhibits the production of lipid peroxide caused by ultraviolet light …

Micropatterned substrates are often used to standardize cell experiments and to
quantitatively study the relation between cell shape and function. Moreover, they are …