From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's
biochemical dissection of β-amyloid in 1984, the" amyloid hypothesis" of Alzheimer's …

Extensive β‐amyloid (Aβ) deposits in brain parenchyma in the form of senile plaques and in
blood vessels in the form of amyloid angiopathy are pathological hallmarks of Alzheimer′ s …

Obesity is associated with increased risk for cardiovascular health problems including
diabetes, hypertension, and stroke. These cardiovascular afflictions increase risk for …

Alzheimer's disease (AD) is the most common form of senile dementia and the fourth highest
cause of disability and death in the elderly. Amyloid-β (Aβ) has been widely implicated in the …

Insulin-degrading enzyme (IDE), an enzyme that primarily degrades insulin, has recently
been demonstrated to play a significant role in the catabolism of amyloid β (Aβ) protein in …

The traditional approach in case-control association studies, to evaluate candidate genes
individually, either single markers or haplotypes, has had limited success. The multifactorial …

Genetic factors have a variable impact on Alzheimer's Disease (AD), ranging from familial
forms that are transmitted in an autosomal dominant fashion to sporadic AD, where a …

In order to perform their normal physiological functions, it is important that cells maintain the
intracellular pH within the physiological range. Intracellular enzyme activity, cytoskeleton …

Abstract Background Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D)
has been well established. Cyclo (His-Pro) plus zinc (Cyclo-Z) treatment ameliorated …

Deletion of insulin-degrading enzyme (IDE) in mice causes accumulation of cerebral
amyloid β-protein (Aβ), hyperinsulinemia, and glucose intolerance. Together with genetic …