Process intensification in biomanufacturing has attracted a great deal of interest in recent
years. Manufacturing platform improvements leading to higher cell density and bioreactor …

Continuous biomanufacturing of recombinant therapeutic proteins offers several potential
advantages over conventional batch processing, including reduced cost of goods, more …

Influenza remains a serious global health concern, causing significant morbidity and
mortality each year. Vaccination is crucial to mitigate its impact, but requires rapid and …

In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess
(ICB) designed for the production of acid‐sensitive monoclonal antibodies, prone to …

The N-linked glycosylation pattern is an important quality attribute of therapeutic
glycoproteins. It has been reported by our group and by others that different carbon sources …

Respiratory diseases including influenza A virus (IAV) infections represent a major threat to
human health. While the development of a vaccine requires a lot of time, a fast …

Retroviral vectors derived from murine leukemia virus (MLV) are used in somatic gene
therapy applications eg for genetic modification of hematopoietic stem cells. Recently, we …

Suspension cultures of Chinese hamster ovary (CHO) cells are extensively employed in
biopharmaceutical production. During cultivation, CHO cell clusters often form due to cell …

Control and prevention of rapid influenza spread among humans depend on the availability
of efficient and safe seasonal and pandemic vaccines, made primarily from inactivated …

In this study, we investigated the effects of alternating tangential flow (ATF) cell separation
on high‐density perfusion cultures. We have developed methods to estimate theoretical …