DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

Transcription poses a threat to genomic stability through the formation of R-loops that can
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …

RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …

R-loops are ubiquitous, dynamic nucleic-acid structures that play fundamental roles in DNA
replication and repair, chromatin and transcription regulation, as well as telomere …

Transcriptional R loops are anomalous RNA: DNA hybrids that have been detected in
organisms from bacteria to humans. These structures have been shown in eukaryotes to …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Whereas chromosomal translocations are common pathogenetic events in cancer,
mechanisms that promote them are poorly understood. To elucidate translocation …

Genomic instability in the form of mutations and chromosome rearrangements is usually
associated with pathological disorders, and yet it is also crucial for evolution. Two types of …

A cursory look at any textbook image of DNA replication might suggest that the complex
machine that is the replisome runs smoothly along the chromosomal DNA. However, many …