Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis

CR Ferraz, A Arrahman, C Xie, NR Casewell… - Frontiers in ecology …, 2019 - frontiersin.org
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …

Mast cell-mediated mechanisms of nociception

A Aich, LB Afrin, K Gupta - International journal of molecular sciences, 2015 - mdpi.com
Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-
attractants, vasoactive compounds, neuropeptides and growth factors in response to …

Edema, hyperalgesia and myonecrosis induced by Brazilian bothropic venoms: Overview of the last decade

CCN Mamede, BB de Sousa Simamoto… - Toxicon, 2020 - Elsevier
Snakebite accidents are considered serious public health problems. They are often
neglected, and individuals who have received insufficient treatment are subjected to various …

Proteomic analysis reveals geographic variation in venom composition of Russell's Viper in the Indian subcontinent: Implications for clinical manifestations post …

B Kalita, SP Mackessy… - Expert review of proteomics, 2018 - Taylor & Francis
ABSTRACT Introduction: The Russell's Viper (RV)(Daboia russelii), a category I medically
important snake, is responsible for a significant level of morbidity and mortality in the Indian …

Photobiomodulation Therapy to Treat Snakebites Caused by Bothrops atrox: A Randomized Clinical Trial

É da Silva Carvalho… - JAMA Internal …, 2024 - jamanetwork.com
Importance Bothropsvenom acts almost immediately at the bite site and causes tissue
damage. Objective To investigate the feasibility and explore the safety and efficacy of low …

Mass spectrometric analysis to unravel the venom proteome composition of Indian snakes: Opening new avenues in clinical research

A Chanda, AK Mukherjee - Expert Review of Proteomics, 2020 - Taylor & Francis
ABSTRACT Introduction The 'Big Four'venomous snakes–Daboia russelii, Naja naja,
Bungarus caeruleus, and Echis carinatus–are primarily responsible for the majority of snake …

Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives

J dos Santos Cavalcante, FAN Júnior, RJB Jorge… - Toxicon, 2021 - Elsevier
Snake venoms are substances mostly composed by proteins and peptides with high
biological activity. Local and systemic effects culminate in clinical manifestations induced by …

Inflammatory Reaction Induced by Two Metalloproteinases Isolated from Bothrops atrox Venom and by Fragments Generated from the Hydrolysis of Basement …

MT Almeida, LA Freitas-de-Sousa, M Colombini… - Toxins, 2020 - mdpi.com
Snake venom metalloproteinases (SVMPs) play an important role in local tissue damage of
snakebite patients, mostly by hydrolysis of basement membrane (BM) components. We …

Therapeutic potential of venom peptides: Insights in the nanoparticle-mediated venom formulations

AV Joglekar, D Dehari, MM Anjum, N Dulla… - Future Journal of …, 2022 - Springer
Background Venoms are the secretions produced by animals, generally for the purpose of
self-defense or catching a prey. Biochemically venoms are mainly composed of proteins …

Evaluation of anti-inflammatory potential of aqueous extract and polysaccharide fraction of Thuja occidentalis Linn. in mice

IS Silva, LAD Nicolau, FBM Sousa, S de Araújo… - International journal of …, 2017 - Elsevier
Inflammation is a protective reaction of the microcirculation. However, sustained
inflammation can lead to undesired effects. Thuja occidentalis Linn has many …