Total body potassium content and proper distribution of potassium across the cell membrane
is of critical importance for normal cellular function. Potassium homeostasis is maintained by …

Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Electrolytes are essential for basic life functioning, such as maintaining electrical neutrality in
cells, generating and conducting action potentials in the nerves and muscles. Sodium …

Potassium homeostasis has a very high priority because of its importance for membrane
potential. Although extracellular K+ is only 2% of total body K+, our physiology was …

Regulated Na+ transport in the distal nephron is of fundamental importance to fluid and
electrolyte homeostasis. Further upstream, Na+ is the principal driver of secondary active …

Kir4. 1 in the distal convoluted tubule plays a key role in sensing plasma potassium and in
modulating the thiazide-sensitive sodium-chloride cotransporter (NCC). Here we tested …

The kidney tubules provide homeostasis by maintaining the external milieu that is critical for
proper cellular function. Without homeostasis, there would be no heartbeat, no muscle …

The World Health Organization ranks hypertension the leading global risk factor for disease,
specifically, cardiovascular disease. Blood pressure (BP) is higher in Westernized …

Membrane voltage controls the function of excitable cells and is mainly a consequence of
the ratio between the extra-and intracellular potassium concentration. Potassium …

Supplementing diets with high potassium helps reduce hypertension in humans. Inwardly
rectifying K+ channels K ir 4.1 (Kcnj10) and K ir 5.1 (Kcnj16) are highly expressed in the …