Altered glycosylation in cancer: A promising target for biomarkers and therapeutics
Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …
Site-specific protein O-glycosylation modulates proprotein processing—deciphering specific functions of the large polypeptide GalNAc-transferase gene family
TBGS Katrine, H Clausen - Biochimica et Biophysica Acta (BBA)-General …, 2012 - Elsevier
BACKGROUND: Posttranslational modifications (PTMs) greatly expand the function and
regulation of proteins, and glycosylation is the most abundant and diverse PTM. Of the many …
regulation of proteins, and glycosylation is the most abundant and diverse PTM. Of the many …
LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1
Y Shan, J Ma, Y Pan, J Hu, B Liu, L Jia - Cell death & disease, 2018 - nature.com
Accumulating evidence suggests long noncoding RNAs (lncRNAs) play an important role in
cancer progression. However, the function of lncRNA SNHG7 in colorectal cancer (CRC) …
cancer progression. However, the function of lncRNA SNHG7 in colorectal cancer (CRC) …
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression
Y Li, C Zeng, J Hu, Y Pan, Y Shan, B Liu… - Journal of hematology & …, 2018 - Springer
Background Colorectal cancer (CRC) arises in a multistep molecular network process,
which is from either discrete genetic perturbation or epigenetic dysregulation. The long non …
which is from either discrete genetic perturbation or epigenetic dysregulation. The long non …
Organelle specific O-glycosylation drives MMP14 activation, tumor growth, and metastasis
Cancers grow within tissues through molecular mechanisms still unclear. Invasiveness
correlates with perturbed O-glycosylation, a covalent modification of cell-surface proteins …
correlates with perturbed O-glycosylation, a covalent modification of cell-surface proteins …
[HTML][HTML] Short O-GalNAc glycans: regulation and role in tumor development and clinical perspectives
J Chia, G Goh, F Bard - Biochimica Et Biophysica Acta (BBA)-General …, 2016 - Elsevier
Background While the underlying causes of cancer are genetic modifications, changes in
cellular states mediate cancer development. Tumor cells display markedly changed …
cellular states mediate cancer development. Tumor cells display markedly changed …
The Cosmc connection to the Tn antigen in cancer
The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in
peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of …
peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of …
Biosynthetic machinery involved in aberrant glycosylation: promising targets for developing of drugs against cancer
A Vasconcelos-dos-Santos, IA Oliveira… - Frontiers in …, 2015 - frontiersin.org
Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …
GALNTs: master regulators of metastasis-associated epithelial-mesenchymal transition (EMT)?
EM Beaman, DRF Carter, SA Brooks - Glycobiology, 2022 - academic.oup.com
In humans, the UDP-N-α-D galactosamine: polypeptide N-acetylgalactosaminyltransferases
family (ppGalNAc-Ts, GalNAc-Ts or GALNTs) comprises 20 isoenzymes. They are …
family (ppGalNAc-Ts, GalNAc-Ts or GALNTs) comprises 20 isoenzymes. They are …
Deconstruction of O‐glycosylation—Gal NA c‐T isoforms direct distinct subsets of the O‐glycoproteome
Gal NA c‐type O‐glycosylation is found on most proteins trafficking through the secretory
pathway in metazoan cells. The O‐glycoproteome is regulated by up to 20 polypeptide Gal …
pathway in metazoan cells. The O‐glycoproteome is regulated by up to 20 polypeptide Gal …