[HTML][HTML] Bacterial multidrug efflux pumps: mechanisms, physiology and pharmacological exploitations

J Sun, Z Deng, A Yan - Biochemical and biophysical research …, 2014 - Elsevier
Multidrug resistance (MDR) refers to the capability of bacterial pathogens to withstand lethal
doses of structurally diverse drugs which are capable of eradicating non-resistant strains …

The TetR family of regulators

L Cuthbertson, JR Nodwell - Microbiology and Molecular Biology …, 2013 - Am Soc Microbiol
The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

The TetR family of transcriptional repressors

JL Ramos, M Martínez-Bueno… - Microbiology and …, 2005 - Am Soc Microbiol
We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

[HTML][HTML] Efflux-mediated multiresistance in Gram-negative bacteria

K Poole - Clinical Microbiology and infection, 2004 - Elsevier
Multiresistance in Gram-negative pathogens, particularly Pseudomonas aeruginosa,
Stenotrophomonas maltophilia, Acinetobacter spp. and the Enterobacteriaceae, is a …

Bacterial membrane transporter systems for aromatic compounds: regulation, engineering, and biotechnological applications

I Mutanda, J Sun, J Jiang, D Zhu - Biotechnology Advances, 2022 - Elsevier
Aromatic compounds are ubiquitous in nature; they are the building blocks of abundant
lignin, and constitute a substantial proportion of synthetic chemicals and organic pollutants …

Members of the IclR family of bacterial transcriptional regulators function as activators and/or repressors

AJ Molina-Henares, T Krell… - FEMS microbiology …, 2006 - academic.oup.com
Members of the IclR family of regulators are proteins with around 250 residues. The IclR
family is best defined by a profile covering the effector binding domain. This is supported by …

Transcriptional tradeoff between metabolic and stress-response programs in Pseudomonas putida KT2440 cells exposed to toluene

P Domínguez-Cuevas, JE González-Pastor… - Journal of Biological …, 2006 - ASBMB
When Pseudomonas putida KT2440 cells encounter toluene in the growth medium, they
perceive it simultaneously as a potential nutrient to be metabolized, as a membrane …

Proteomic Analysis Reveals the Participation of Energy- and Stress-Related Proteins in the Response of Pseudomonas putida DOT-T1E to Toluene

A Segura, P Godoy, P van Dillewijn… - Journal of …, 2005 - Am Soc Microbiol
ABSTRACT Pseudomonas putida DOT-T1E is tolerant to toluene and other toxic
hydrocarbons through extrusion of the toxic compounds from the cell by means of three …

Antibiotic-Dependent Induction of Pseudomonas putida DOT-T1E TtgABC Efflux Pump Is Mediated by the Drug Binding Repressor TtgR

W Terán, A Felipe, A Segura, A Rojas… - Antimicrobial Agents …, 2003 - Am Soc Microbiol
Pseudomonas putida is well known for its metabolic capabilities, but recently, it has been
shown to exhibit resistance to a wide range of antibiotics. In P. putida DOT-T1E, the TtgABC …

Microbial resistance: The role of efflux pump superfamilies and their respective substrates

ÍR Garcia, FA de Oliveira Garcia, PS Pereira… - Life Sciences, 2022 - Elsevier
The microorganism resistance to antibiotics has become one of the most worrying issues for
science due to the difficulties related to clinical treatment and the rapid spread of diseases …