Current and future biomarkers in multiple sclerosis

J Yang, M Hamade, Q Wu, Q Wang, R Axtell… - International journal of …, 2022 - mdpi.com
Multiple sclerosis (MS) is a debilitating autoimmune disorder. Currently, there is a lack of
effective treatment for the progressive form of MS, partly due to insensitive readout for …

Neuropsychiatric lupus: new mechanistic insights and future treatment directions

N Schwartz, AD Stock, C Putterman - Nature Reviews Rheumatology, 2019 - nature.com
Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

Mechanisms of autoantibody-induced pathology

RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: frequency, syndrome specificity, influence of disease activity, long-term course …

S Jarius, K Ruprecht, I Kleiter, N Borisow… - Journal of …, 2016 - Springer
Background Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been
suggested to play a role in a subset of patients with neuromyelitis optica and related …

Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS)

C Trebst, S Jarius, A Berthele, F Paul, S Schippling… - Journal of …, 2014 - Springer
Neuromyelitis optica (NMO, Devic's syndrome), long considered a clinical variant of multiple
sclerosis, is now regarded as a distinct disease entity. Major progress has been made in the …

Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes

A Carvajal-Gonzalez, MI Leite, P Waters, M Woodhall… - Brain, 2014 - academic.oup.com
The clinical associations of glycine receptor antibodies have not yet been described fully.
We identified prospectively 52 antibody-positive patients and collated their clinical features …

Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: a multicentre study of 175 patients

S Jarius, K Ruprecht, B Wildemann, T Kuempfel… - Journal of …, 2012 - Springer
Background The diagnostic and pathophysiological relevance of antibodies to aquaporin-4
(AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been …

N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both …

SR Irani, K Bera, P Waters, L Zuliani, S Maxwell… - Brain, 2010 - academic.oup.com
Antibodies to the N-methyl-d-aspartate subtype of glutamate receptor have been associated
with a newly-described encephalopathy that has been mainly identified in young females …

Morvan syndrome: clinical and serological observations in 29 cases

SR Irani, P Pettingill, KA Kleopa, N Schiza… - Annals of …, 2012 - Wiley Online Library
Objective: A study was undertaken to describe the clinical spectrum, voltage‐gated
potassium channel (VGKC) complex antibody specificities, and central nervous system …

Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays

PJ Waters, A McKeon, MI Leite, S Rajasekharan… - Neurology, 2012 - AAN Enterprises
Objectives: Neuromyelitis optica (NMO) immunoglobulin G (IgG)(aquaporin-4 [AQP4] IgG) is
highly specific for NMO and related disorders, and autoantibody detection has become an …