Retroviruses make a long and complex journey from outside the cell to the nucleus in the
early stages of infection, and then an equally long journey back out again in the late stages …

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag
proteins are targeted to the plasma membrane of most hematopoietic cell types, where they …

Generation of infectious retroviral particles rely on the targeting of all structural components
to the correct cellular sites at the correct time. Gag, the main structural protein, orchestrates …

Although all established functions of dengue virus NS5 (nonstructural protein 5) occur in the
cytoplasm, its nuclear localization, mediated by dual nuclear localization sequences, is …

The ability of the retroviral Gag protein of Rous sarcoma virus (RSV) to transiently traffic
through the nucleus is well-established and has been implicated in genomic RNA (gRNA) …

Cellular mRNAs are exported from the nucleus as fully spliced RNAs. Proofreading
mechanisms eliminate unprocessed and irregular pre-mRNAs to control the quality of gene …

Retroviral Gag polyproteins coopt host factors to traffic from cytosolic ribosomes to the
plasma membrane, where virions are released. Before membrane transport, the …

The packaging of retroviral genomic RNA (gRNA) requires cis-acting elements within the
RNA and trans-acting elements within the Gag polyprotein. The packaging signal ψ, at the …

Background Chikungunya virus (CHIKV) is an alphavirus of the Togaviridae family. After
autoproteolytic cleavage, the CHIKV capsid protein (CP) is involved in RNA binding and …

Gag nuclear localization has long been recognized as a hallmark of foamy virus (FV)
infection. Two required motifs, a chromatin-binding site (CBS) and a nuclear localization …