Andrographolide is compound extracted from Andrographis paniculata (A. paniculata), a
traditional herb that has been used in ancient China and other parts of eastern Asia to treat …

Chronic hepatitis B virus (HBV) infection remains to be a substantial global burden,
especially for end-stage liver diseases. It is well accepted that HBV-specific T and B cells are …

Abstract Background & Aims Liver diseases resulting from chronic HBV infection are a
significant cause of morbidity and mortality. Vaccines that elicit T-cell responses capable of …

Survival of gastrointestinal cancer remains dismal, especially for metastasized disease. For
various cancers, especially melanoma and lung cancer, immunotherapy has been proven to …

Viral infectious diseases have resulted in millions of deaths throughout history and have
created a significant public healthcare burden. Tremendous efforts have been placed by the …

Background & Aims Antigen-specific immunotherapy is a promising strategy to treat HBV
infection and hepatocellular carcinoma (HCC). To facilitate killing of malignant and/or …

Introduction Therapeutic vaccination based on synthetic long peptides (SLP®) containing
both CD4+ and CD8+ T cell epitopes is a promising treatment strategy for chronic hepatitis B …

Synthetic long peptides (SLPs) are a promising vaccine modality that exploit dendritic cells
(DC) to treat chronic infections or cancer. Currently, the design of SLPs relies on in silico …

The induction of CTL responses by vaccines is important to combat infectious diseases and
cancer. Biodegradable poly (lactic-co-glycolic acid)(PLGA) microspheres and synthetic long …

In the mid‐90s, hepatitis B virus (HBV)‐directed immune responses were for the first time
investigated in detail and revealed suboptimal T‐cell responses in chronic HBV patients …