Gut-derived systemic inflammation as a driver of depression in chronic liver disease

VT Kronsten, TH Tranah, C Pariante… - Journal of hepatology, 2022 - Elsevier
Depression and chronic liver disease (CLD) are important causes of disability, morbidity and
mortality worldwide and their prevalence continues to rise. The rate of depression in CLD is …

[HTML][HTML] Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease

A Katsarou, II Moustakas, I Pyrina… - World journal of …, 2020 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids
in the form of triglycerides in hepatocytes. It is most prevalent in western countries and …

[HTML][HTML] Origin and function of stress-induced IL-6 in murine models

H Qing, R Desrouleaux, K Israni-Winger, YS Mineur… - Cell, 2020 - cell.com
Acute psychological stress has long been known to decrease host fitness to inflammation in
a wide variety of diseases, but how this occurs is incompletely understood. Using mouse …

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

Y Yu, Y Liu, W An, J Song, Y Zhang… - The Journal of clinical …, 2019 - Am Soc Clin Investig
Innate immune activation contributes to the transition from nonalcoholic fatty liver to
nonalcoholic steatohepatitis (NASH). Stimulator of IFN genes (STING, also referred to …

Lysophosphatidylethanolamine affects lipid accumulation and metabolism in a human liver-derived cell line

Y Yamamoto, T Sakurai, Z Chen, N Inoue, H Chiba… - Nutrients, 2022 - mdpi.com
The physiological functions of lysophosphatidylethanolamine (lysoPE) have not been fully
elucidated. In this study, the effects of lysoPE on lipogenesis and lipolysis were investigated …

[HTML][HTML] Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid …

J Hu, H Wang, X Li, Y Liu, Y Mi, H Kong, D Xi, W Yan… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: The functions of fibrinogen-like protein 2 (fgl2) have been studied in many
inflammatory and neoplastic diseases, but the role of fgl2 in nonalcoholic fatty liver disease …

[HTML][HTML] Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder

C Du, S Zheng, Y Yang, X Feng, J Chen, Y Tang… - Ecotoxicology and …, 2022 - Elsevier
Abstract Microcystin-LR (MC-LR), a potent hepatotoxin can cause liver damages. However,
research on hepatic lipid metabolism caused by long-term exposure to environmental …

Abnormal metabolic processes involved in the pathogenesis of non‑alcoholic fatty liver disease

M Shao, Z Ye, Y Qin, T Wu - Experimental and …, 2020 - spandidos-publications.com
Non‑alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
and can lead to liver cirrhosis or liver cancer in severe cases. In recent years, the incidence …

Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype

SJB Snelling, S Bas, GJ Puskas, SG Dakin, D Suva… - PloS one, 2017 - journals.plos.org
Purpose Osteoarthritis (OA) is a common and heterogeneous arthritic disorder. Patients
suffer pain and their joints are characterized by articular cartilage loss and osteophyte …

Lycopene improves insulin sensitivity through inhibition of STAT3/Srebp-1c-mediated lipid accumulation and inflammation in mice fed a high-fat diet

Z Zeng, W He, Z Jia, S Hao - Experimental and clinical …, 2017 - thieme-connect.com
In the past few years, metabolic disorders, such as type 2 diabetes and metabolic syndrome,
have reached global prevalence. Lycopene is one of the major carotenoids in tomatoes …