The machines that divide and fuse mitochondria
Mitochondria are derived from eubacteria; however, in most eukaryotes, novel mechanisms
for the propagation of this organelle and its genome have evolved. This review focuses on …
for the propagation of this organelle and its genome have evolved. This review focuses on …
Structure-function relationships of the G domain, a canonical switch motif
A Wittinghofer, IR Vetter - Annual review of biochemistry, 2011 - annualreviews.org
GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …
Structural insights into oligomerization and mitochondrial remodelling of dynamin 1‐like protein
C Fröhlich, S Grabiger, D Schwefel, K Faelber… - The EMBO …, 2013 - embopress.org
Dynamin 1‐like protein (DNM1L) mediates fission of mitochondria and peroxisomes, and
dysfunction of DNM1L has been implicated in several neurological disorders. To study the …
dysfunction of DNM1L has been implicated in several neurological disorders. To study the …
Crystal structure of nucleotide-free dynamin
K Faelber, Y Posor, S Gao, M Held, Y Roske… - Nature, 2011 - nature.com
Dynamin is a mechanochemical GTPase that oligomerizes around the neck of clathrin-
coated pits and catalyses vesicle scission in a GTP-hydrolysis-dependent manner. The …
coated pits and catalyses vesicle scission in a GTP-hydrolysis-dependent manner. The …
G domain dimerization controls dynamin's assembly-stimulated GTPase activity
Dynamin is an atypical GTPase that catalyses membrane fission during clathrin-mediated
endocytosis. The mechanisms of dynamin's basal and assembly-stimulated GTP hydrolysis …
endocytosis. The mechanisms of dynamin's basal and assembly-stimulated GTP hydrolysis …
The crystal structure of dynamin
MGJ Ford, S Jenni, J Nunnari - Nature, 2011 - nature.com
Dynamin-related proteins (DRPs) are multi-domain GTPases that function via
oligomerization and GTP-dependent conformational changes to play central roles in …
oligomerization and GTP-dependent conformational changes to play central roles in …
Dynamin: functional design of a membrane fission catalyst
SL Schmid, VA Frolov - Annual review of cell and …, 2011 - annualreviews.org
Dynamin, best studied for its role in clathrin-mediated endocytosis, is the prototypical
member of a family of multidomain GTPases involved in fission and remodeling of multiple …
member of a family of multidomain GTPases involved in fission and remodeling of multiple …
Structural basis of oligomerization in the stalk region of dynamin-like MxA
S Gao, A von der Malsburg, S Paeschke, J Behlke… - Nature, 2010 - nature.com
The interferon-inducible dynamin-like myxovirus resistance protein 1 (MxA; also called MX1)
GTPase is a key mediator of cell-autonomous innate immunity against pathogens such as …
GTPase is a key mediator of cell-autonomous innate immunity against pathogens such as …
[HTML][HTML] A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke
The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of
clathrin-coated pits, but the specific structural interactions and conformational changes that …
clathrin-coated pits, but the specific structural interactions and conformational changes that …
Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling
The ability to actively remodel membranes in response to nucleotide hydrolysis has largely
been attributed to GTPases of the dynamin superfamily, and these have been extensively …
been attributed to GTPases of the dynamin superfamily, and these have been extensively …