Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Cytotoxic effects, carbonic anhydrase isoenzymes, α-glycosidase and acetylcholinesterase inhibitory properties, and molecular docking studies of heteroatom …
Today, interest in studies on the search for new drugs to be used in diseases such as
cancer, cardiovascular diseases, neurodegenerative diseases and diabetes, as well as …
cancer, cardiovascular diseases, neurodegenerative diseases and diabetes, as well as …
Synthesis and radical scavenging activity of new phenolic hydrazone/hydrazide derivatives: Experimental and theoretical studies
Hydrazone and hydrazone-hydrazide-based compounds represent important classes of
compounds that continue to attract increasing interest due to their diverse pharmacological …
compounds that continue to attract increasing interest due to their diverse pharmacological …
Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers
In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate
moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy …
moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy …
Selective COX-2 inhibitors as anticancer agents: a patent review (2018-2023)
M Mahboubi-Rabbani, AH Abdolghaffari… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's
metabolites might have an important function as regulators of the inflammatory response …
metabolites might have an important function as regulators of the inflammatory response …
[HTML][HTML] In silico and pharmacokinetic assessment of echinocystic acid effectiveness in Alzheimer's disease like pathology
A Singh, C Vellapandian - Future Science OA, 2024 - ncbi.nlm.nih.gov
Aim: Alzheimer's disease causes dementia which impairs the cognitive domains.
Methodology: The pharmacokinetic characteristics and biological activity of echinocystic …
Methodology: The pharmacokinetic characteristics and biological activity of echinocystic …
Therapeutic study of cinnamic acid derivative for oxidative stress ablation: The computational and experimental answers
This study aimed to examine the therapeutic activity of the cinnamic acid derivative KAD-7
(N′-(2, 4-dichlorobenzylidene)-3-(4-methoxyphenyl) acrylohydrazide) on Fe2+-induced …
(N′-(2, 4-dichlorobenzylidene)-3-(4-methoxyphenyl) acrylohydrazide) on Fe2+-induced …
Ultrasonic-induced synthesis of novel diverse arylidenes via Knoevenagel condensation reaction. Antitumor, QSAR, docking and DFT assessment
EES Ebead, A Aboelnaga, E Nassar, MM Naguib… - RSC …, 2023 - pubs.rsc.org
A series of arylidenes derivatives was synthesized under ultrasonic methodology via
Knoevenagel condensation reaction of cyanoacetohydrazide derivative with the appropriate …
Knoevenagel condensation reaction of cyanoacetohydrazide derivative with the appropriate …
Design, synthesis, and characterization of cinnamic acid derivatives with two novel acrylohydrazones on HeLa and CHO-1 cancer cell lines: the experimental and …
Purpose To investigate the effect of derivatives of cinnamic acid on the proliferation of CHO-
1 and HeLa cell lines. Methods Three Acrylohydrazones (7–9) derived from cinnamic acid …
1 and HeLa cell lines. Methods Three Acrylohydrazones (7–9) derived from cinnamic acid …