Why does obesity cause diabetes?
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …
Obesity and the risk of cardiometabolic diseases
PL Valenzuela, P Carrera-Bastos… - Nature reviews …, 2023 - nature.com
The prevalence of obesity has reached pandemic proportions, and now approximately 25%
of adults in Westernized countries have obesity. Recognized as a major health concern …
of adults in Westernized countries have obesity. Recognized as a major health concern …
Adipose tissue at single-cell resolution
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …
composition under physiological and pathophysiological conditions. The emergence of …
[HTML][HTML] An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease
E Lee, H Korf, A Vidal-Puig - Journal of hepatology, 2023 - Elsevier
Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …
homeostasis. Although each organ has its specialised functions, they must work …
Angiogenesis in adipose tissue and obesity
While most tissues exhibit their greatest growth during development, adipose tissue is
capable of additional massive expansion in adults. Adipose tissue expandability is …
capable of additional massive expansion in adults. Adipose tissue expandability is …
White adipocyte dysfunction and obesity-associated pathologies in humans
CE Hagberg, KL Spalding - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …
worldwide, negatively impacting on societies and economies. Whereas the association …
Associations among adipose tissue immunology, inflammation, exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease
Background And Aims Insulin resistance is a key factor in the pathogenesis of nonalcoholic
fatty liver disease (NAFLD). We evaluated the importance of subcutaneous abdominal …
fatty liver disease (NAFLD). We evaluated the importance of subcutaneous abdominal …
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …
The role of glp-1 receptor agonists in insulin resistance with concomitant obesity treatment in polycystic ovary syndrome
K Bednarz, K Kowalczyk, M Cwynar, D Czapla… - International journal of …, 2022 - mdpi.com
Insulin resistance is documented in clamp studies in 75% of women with polycystic ovary
syndrome (PCOS). Although it is not included in the diagnostic criteria of PCOS, there is a …
syndrome (PCOS). Although it is not included in the diagnostic criteria of PCOS, there is a …
Adipose tissue secretion pattern influences β-cell wellness in the transition from obesity to type 2 diabetes
The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …