Gut–liver axis: barriers and functional circuits

O Pabst, MW Hornef, FG Schaap, V Cerovic… - Nature Reviews …, 2023 - nature.com
The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

Metabolism and colorectal cancer

JC Sedlak, ÖH Yilmaz, J Roper - Annual Review of Pathology …, 2023 - annualreviews.org
Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

Tumor microbiome links cellular programs and immunity in pancreatic cancer

B Ghaddar, A Biswas, C Harris, MB Omary, DR Carpizo… - Cancer Cell, 2022 - cell.com
Microorganisms are detected in multiple cancer types, including in putatively sterile organs,
but the contexts in which they influence oncogenesis or anti-tumor responses in humans …

Interaction between the microbiota, epithelia, and immune cells in the intestine

H Kayama, R Okumura, K Takeda - Annual review of …, 2020 - annualreviews.org
The gastrointestinal tract harbors numerous commensal bacteria, referred to as the
microbiota, that benefit host health by digesting dietary components and eliminating …

[HTML][HTML] Targeting gut microbiota and metabolism as the major probiotic mechanism-An evidence-based review

T Ma, X Shen, X Shi, HA Sakandar, K Quan, Y Li… - Trends in Food Science …, 2023 - Elsevier
Background The human gut hosts complex microbial communities, which are linked to
health and disease. The gut microbiota is continuously reshaped by multiple environmental …

[HTML][HTML] Metabolite interactions between host and microbiota during health and disease: Which feeds the other?

Y Zhang, R Chen, DD Zhang, S Qi, Y Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …

Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon

TP Brown, V Ganapathy - Pharmacology & therapeutics, 2020 - Elsevier
Reprogramming of biochemical pathways is a hallmark of cancer cells, and generation of
lactic acid from glucose/glutamine represents one of the consequences of such metabolic …

Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota

S Sun, X Xu, L Liang, X Wang, X Bai, L Zhu… - Frontiers in …, 2021 - frontiersin.org
Lactic acid, a metabolic by-product of host and intestinal microbiota, has been recovered as
an active signal molecule in the immune system. In this study, a lactic acid biosynthesis …

Impact of enteric bacterial infections at and beyond the epithelial barrier

AP Rogers, SJ Mileto, D Lyras - Nature Reviews Microbiology, 2023 - nature.com
The mucosal lining of the gut has co-evolved with a diverse microbiota over millions of
years, leading to the development of specialized mechanisms to actively limit the invasion of …

New insights into gut-bacteria-derived indole and its derivatives in intestinal and liver diseases

X Li, B Zhang, Y Hu, Y Zhao - Frontiers in Pharmacology, 2021 - frontiersin.org
The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …