Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC),
ranks the fourth leading cause of cancer-related deaths in the western world. While the …

Pancreatic cancer (PC) is the fourth most common cause of death among all cancers. Poor
prognosis of PC may be caused by a prevalence of cancer stem cells (CSCs). CSCs are a …

The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a
hardwired defined entity has evolved our understanding of the functional and biological …

Iron is indispensable for cell metabolism of both normal and cancer cells. In the latter,
several disruptions of its metabolism occur at the steps of tumor initiation, progression and …

Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide
due to late diagnosis and early metastasis, with a 1-year overall survival rate of …

Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive
oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most overlooked cancers despite its
dismal median survival time of 6 months. The biggest challenges in improving patient …

Chemotherapy and immunotherapy for pancreatic ductal adenocarcinoma (PDAC) have
limited success. One reason for this is thought to be the cancer microenvironment …

Tumor-associated macrophages (TAMs) contribute to the maintenance of a strong
immunosuppressive environment, supporting tumor progression and resistance to treatment …