Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Microtubule-targeting agents (MTAs) have demonstrated remarkable efficacy as antitumor,
antifungal, antiparasitic, and herbicidal agents, finding applications in the clinical, veterinary …

Regulation of directed axon guidance and branching during development is essential for the
generation of neuronal networks. However, the molecular mechanisms that underlie …

Microtubules have spatiotemporally complex posttranslational modification patterns. Tubulin
tyrosine ligase-like (TTLL) enzymes introduce the most prevalent modifications on α-tubulin …

Post-translational cycles of α-tubulin detyrosination and tyrosination generate microtubule
diversity, the cellular functions of which remain largely unknown. Here we show that α …

Despite the importance of cellular senescence in human health, how damaged cells
undergo senescence remains elusive. We have previously shown that promyelocytic …

Liquid-liquid reactions play a significant role in organic synthesis. However, control of the
phase interface between incompatible two-phase liquids remains challenging. Moreover …

The technology of native chemical ligation and postligation desulfurization has greatly
expanded the scope of modern chemical protein synthesis. Here, we report that ultrasonic …

Highlights•Tubulin posttranslational modifications (PTMs) can affect neurotransmission and
synaptic plasticity.•Disturbances in tubulin PTMs can lead to neurodegeneration.•Tubulin …

Abstract The Tubulin Code revolutionizes our understanding of microtubule dynamics and
functions, proposing a nuanced system governed by tubulin isotypes, posttranslational …