This review covers the literature published between January and December in 2018 for
marine natural products (MNPs), with 717 citations (706 for the period January to December …

Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different
molecular scaffolds reported to date. These venom components have traditionally been …

The 2018 marine pharmacology literature review represents a continuation of the previous
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …

Toxins from marine animals provide molecular tools for the study of many ion channels,
including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity …

Abstract Background The ShK toxin from Stichodactyla helianthus has established the
therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin …

Bioactive compounds are abundant in animals originating from marine ecosystems. Ion
channels, which include sodium, potassium, calcium, and chloride, together with their …

As primitive metazoa, sea anemones are rich in various bioactive peptide neurotoxins.
These peptides have been applied to neuroscience research tools or directly developed as …

CRISPs represent a family of cysteine-rich secretory proteins with molecular mass between
20 and 30 kDa and a highly conserved specific pattern of 16 cysteine residues. In this work …

Among voltage-gated potassium channel (KV) isoforms, KV 1.6 is one of the most
widespread in the nervous system. However, there are little data concerning its …

The effect of peptide toxins on voltage-gated ion channels can be reliably assessed using
electrophysiological assays, such as the patch-clamp technique. However, much of the …