As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-
derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its …

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …

Abstract Retinoic acid-induced 1 (RAI1) haploinsufficiency causes Smith–Magenis
syndrome (SMS), a genetic disorder with symptoms including hyperphagia, hyperlipidemia …

Epileptic encephalopathies are generally considered to be functional disruptions in the
balance between neural excitation and inhibition. Excitatory and inhibitory voltage-gated ion …

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in MECP2,
which encodes methyl-CpG-binding protein 2, a transcriptional regulator of many genes …

Dravet syndrome (DS) is a devastating developmental epileptic encephalopathy marked by
treatment-resistant seizures, developmental delay, intellectual disability, motor deficits, and …

Genetic variation accounts for much of the risk for developing a substance use disorder, but
the underlying genetic factors and their genetic effector mechanisms are mostly unknown …

Tropomyosin receptor kinase B (TrkB) signaling plays a pivotal role in dendritic growth and
dendritic spine formation to promote learning and memory. The activity-dependent release …

Genetic variation accounts for much of the risk for developing a substance use disorder
(SUD). Inbred mouse strains exhibit substantial and heritable differences in the extent of …

Dravet syndrome caused by SCN1A variants is a severe developmental epileptic
encephalopathy (DEE) characterized by pharmaco-resistant epileptic seizures and …