Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

Twenty years of investigation have yielded a detailed view of the signalling machinery
engaged by T-cell receptors (TCRs). Many of the fundamental insights into TCR signalling …

T cell receptor (TCR) activation and signaling precede immunological synapse formation
and are sustained for hours after initiation. However, the precise physical sites of the initial …

To become activated, T cells must efficiently recognize antigen-presenting cells or target
cells through several complex cytoskeleton-dependent processes, including integrin …

T cell cytoarchitecture differs dramatically depending on whether the cell is circulating within
the bloodstream, migrating through tissues, or interacting with antigen-presenting cells. The …

T‐cell activation requires 'contact'with antigen‐presenting cells (APCs) to bring the T‐cell
receptor (TCR) and antigenic major histocompatibility complex (MHC)‐peptide complex …

SLP76 and SLP65 are adaptor proteins that lack intrinsic enzymatic activity but contain
multiple protein-binding domains. These proteins are essential for signalling downstream of …

The Vav family proteins (Vav1, Vav2, Vav3) are cytoplasmic guanine nucleotide exchange
factors (GEFs) for Rho-family GTPases. T-cell antigen receptor (TCR) signalling results in …