The development of synthetic methods for the introduction of the fluorine atom and
fluoroalklyl groups into organic molecules has gained increased attention. Synthetic organic …

This review describes the recent advances made in difluoromethylation processes based on
X–CF2H bond formation where X is C (sp), C (sp2), C (sp3), O, N or S, a field of research …

Transition metal-catalyzed C–H bond functionalizations have been the focus of intensive
research over the last decades for the formation of C–C bonds from unfunctionalized arenes …

The relevance of the‐CF2H moiety has attracted considerable attention from organic
synthetic and medicinal chemistry communities, because this group can act as a more …

The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible‐
light photoredox catalysis. A wide range of readily available mono‐, di‐, and trifluoromethyl …

Isocyanides have a broad range of applications in multicomponent reactions such as
Passerini and Ugi processes. Recent advances in metal catalysis have tremendously …

An unprecedented radical difluoromethylarylation reaction of alkynes has been developed
by discovering a new difluoromethylation reagent, CF2HSO2NHNHBoc. This air-stable and …

The direct introduction of diverse fluorinated motifs into feedstock molecules and advanced
intermediates is widely studied in pharmaceutical research and drug development. Among …

Owing to the excellent performance of fluorinated compounds in the areas of
pharmaceuticals, agrochemicals, and materials chemistry, organic chemists have made …

Recent protocols and reactions for catalytic radical perfluoroalkylations will be described.
The production of perfluoroalkyl radicals (RF= C n F2 n+ 1, n≥ 2), which effect both addition …