Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy
AJ Marian, E Braunwald - Circulation research, 2017 - Am Heart Assoc
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …
Ribosome-associated quality-control mechanisms from bacteria to humans
S Filbeck, F Cerullo, S Pfeffer, CAP Joazeiro - Molecular cell, 2022 - cell.com
Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …
produced by interrupted translation. Central players in RQC are the human ribosome-and …
Translation‐coupled mRNA quality control mechanisms
L Monaghan, D Longman, JF Cáceres - The EMBO Journal, 2023 - embopress.org
Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
ZNF598 is a quality control sensor of collided ribosomes
Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase
ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and …
ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and …
Ribosome-associated protein quality control
O Brandman, RS Hegde - Nature structural & molecular biology, 2016 - nature.com
Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA,
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …
[HTML][HTML] Ribosome collision is critical for quality control during no-go decay
No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with
translational arrests. The process is characterized by an endonucleolytic cleavage near the …
translational arrests. The process is characterized by an endonucleolytic cleavage near the …
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation
CJ Decker, R Parker - Cold Spring Harbor perspectives …, 2012 - cshperspectives.cshlp.org
The control of translation and mRNA degradation is important in the regulation of eukaryotic
gene expression. In general, translation and steps in the major pathway of mRNA decay are …
gene expression. In general, translation and steps in the major pathway of mRNA decay are …
The DEAD-box protein Dhh1p couples mRNA decay and translation by monitoring codon optimality
A Radhakrishnan, YH Chen, S Martin, N Alhusaini… - Cell, 2016 - cell.com
A major determinant of mRNA half-life is the codon-dependent rate of translational
elongation. How the processes of translational elongation and mRNA decay communicate is …
elongation. How the processes of translational elongation and mRNA decay communicate is …
The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay
Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a
series of quality control events including ribosome rescue, degradation of the stalled …
series of quality control events including ribosome rescue, degradation of the stalled …
The GPR54 Gene as a Regulator of Puberty
SB Seminara, S Messager, EE Chatzidaki… - … England Journal of …, 2003 - Mass Medical Soc
Background Puberty, a complex biologic process involving sexual development, accelerated
linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone …
linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone …