Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

The pancreatic duodenum homeobox-1 (PDX-1) is a transcription factor encoded by a Hox-
like homeodomain gene that plays a crucial role in pancreatic development, β-cell …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

The beta-cell identity gene, pancreatic duodenal homeobox 1 (Pdx1), plays critical roles in
many aspects of the life of beta-cells including differentiation, maturation, function, survival …

Nitric oxide (NO) is a diffusible signaling molecule that modulates animal and plant immune
responses. In addition, reactive nitrogen species derived from NO can display antimicrobial …

Insulin expression is primarily restricted to the pancreatic β cells, which are physically or
functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-β …

Pancreatic ductal adenocarcinoma (PDAC) is believed to arise from the accumulation of a
series of somatic mutations and is also frequently associated with pancreatic intraepithelial …

Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic
dysregulation has been associated with the initiation and progression of pancreatic tumors …

Background Glucose homeostasis is dependent on functional pancreatic α and ß cells. The
mechanisms underlying the generation and maturation of these endocrine cells remain …

The biomimetic pancreatic microenvironment improves the differentiation efficiency and
function of human embryonic stem cell-derived β-cells (S C-β cells). Thus, a laminin subunit …