The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Fibrillar centers (FCs) and dense fibrillar components (DFCs) are essential morphologically
distinct sub-regions of mammalian cell nucleoli for rDNA transcription and pre-rRNA …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

Ribosome biogenesis is a complex and energy-demanding process requiring tight
coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production. Given the …

Mutations that target the ubiquitous process of ribosome assembly paradoxically cause
diverse tissue-specific disorders (ribosomopathies) that are often associated with an …

Abstract The transcription of 18S, 5.8 S, and 18S rRNA genes (45S rDNA), cotranscriptional
processing of pre-rRNA, and assembly of mature rRNA with ribosomal proteins are the …

Eukaryotic small ribosomal subunits are first assembled into 90S pre-ribosomes. The
complete 90S is a gigantic complex with a molecular mass of approximately five …

Despite the rising knowledge about ribosome function and structure and how ribosomal
subunits assemble in vitro in bacteria, the in vivo role of many ribosomal proteins remains …