In recent years several new mouse models for lung cancer have been described. These
include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer …

Inorganic arsenic (iAs) at high exposures is a human carcinogen, affecting mainly the
urinary bladder, lung and skin. We present an assessment of the mode of action (MOA) of …

Alveoli are gas-exchange sacs lined by squamous alveolar type (AT) 1 cells and cuboidal,
surfactant-secreting AT2 cells. Classical studies suggested that AT1 arise from AT2 cells, but …

Antioxidants are widely used to protect cells from damage induced by reactive oxygen
species (ROS). The concept that antioxidants can help fight cancer is deeply rooted in the …

Autophagy is a mechanism by which starving cells can control their energy requirements
and metabolic states, thus facilitating the survival of cells in stressful environments, in …

Cancer evolution determines molecular and morphologic intratumor heterogeneity and
challenges the design of effective treatments. In lung adenocarcinoma, disease progression …

Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell
lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 (miR-21) expression is …

AMPK, a conserved sensor of low cellular energy, can either repress or promote tumor
growth depending on the context. However, no studies have examined AMPK function in …

Gasotransmitters with their cytotoxicity in high concentration have become the focus of
attention. For such concentration depended therapy, how to effectively deliver gases and …

MicroRNAs (miRNAs) have recently emerged as an important new class of cellular
regulators that control various cellular processes and are implicated in human diseases …