Transplant tolerance: new insights and strategies for long‐term allograft acceptance

P Ruiz, P Maldonado, Y Hidalgo… - Journal of …, 2013 - Wiley Online Library
One of the greatest advances in medicine during the past century is the introduction of organ
transplantation. This therapeutic strategy designed to treat organ failure and organ …

Tolerance induction strategies in vascularized composite allotransplantation: mixed chimerism and novel developments

DA Leonard, DA McGrouther, JM Kurtz… - Journal of …, 2012 - Wiley Online Library
Since the start of the clinical vascularized composite allotransplantation (VCA) era over a
decade ago this field has witnessed significant developments in both basic and translational …

[HTML][HTML] The N6-methyladenosine writer WTAP contributes to the induction of immune tolerance post kidney transplantation by targeting regulatory T cells

Z Wang, Y Qi, Y Feng, H Xu, J Wang, L Zhang… - Laboratory …, 2022 - Elsevier
Abstract N6-methyladenosine (m6A) modification is involved in diverse immunoregulation,
while the relationship between m6A modification and immune tolerance post kidney …

Perforin-positive dendritic cells exhibit an immuno-regulatory role in metabolic syndrome and autoimmunity

Y Zlotnikov-Klionsky, B Nathansohn-Levi, E Shezen… - Immunity, 2015 - cell.com
Emerging evidence suggests that immunological mechanisms underlie metabolic control of
adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of …

Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7

L Zangi, Y Zlotnikov Klionsky, L Yarimi… - Blood, The Journal …, 2012 - ashpublications.org
Immature dendritic cells (imDCs) can have a tolerizing effect under normal conditions or
after transplantation. However, because of the significant heterogeneity of this cell …

The need for inducing tolerance in vascularized composite allotransplantation

KV Ravindra, H Xu, LD Bozulic… - Journal of …, 2012 - Wiley Online Library
Successful hand and face transplantation in the last decade has firmly established the field
of vascularized composite allotransplantation (VCA). The experience in VCA has thus far …

Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance

H Xu, DM Ramsey, S Wu, LD Bozulic, ST Ildstad - Transplantation, 2013 - journals.lww.com
Background Approaches to safely induce tolerance in vascularized composite
allotransplantation (VCA) with chimerism through bone marrow transplantation (BMT) are …

Donor-derived bone marrow transfusion produces mixed chimerism and promotes a Th2 shift in Th1/Th2 balance in rat heterotopic small bowel transplantation

A Hu, Q Li, H Shi, Q Tai, L Wu, J Xiong, B Fu… - Digestive and Liver …, 2012 - Elsevier
BACKGROUND AND AIM: In this study, we investigated immunomodulatory effects of donor-
derived bone marrow transfusion in rat heterotopic small bowel transplantation. METHODS …

Increased leakage of brain antigens after traumatic brain injury and effect of immune tolerance induced by cells on traumatic brain injury

YAN Hua, HW Zhang, QL Wu, G Zhang… - Chinese Medical …, 2012 - journals.lww.com
Background Although traumatic brain injury can lead to opening the blood-brain barrier and
leaking of blood substances (including water) into brain tissue, few studies of brain antigens …

[HTML][HTML] PU. 1-silenced dendritic cells induce mixed chimerism and alleviate intestinal transplant rejection in rats via a Th1 to Th2 shift

X Xu, X Gao, X Zhao, Y Liao, W Ji, Q Li… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Intestinal transplantation is an effective treatment for end-stage bowel
failure; however, graft rejection and the toxicity associated with non-specific …