Throughout their life, bacteria need to sense and respond to environmental stress. Thus,
such stress responses can require dramatic cellular reprogramming, both at the …

Ribosomes that stall during translation need to be rescued to ensure that the protein
synthesis capacity of the cell is maintained. Stalling arises when ribosomes become trapped …

DNA transcription is functionally coupled to messenger RNA (mRNA) translation in bacteria,
but how this is achieved remains unclear. Here we show that RNA polymerase (RNAP) and …

Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis
must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue …

An RNA structure prediction from a single‐sequence RNA folding program is not evidence
for an RNA whose structure is important for function. Random sequences have plausible …

Prevailing dogma holds that ribosomes are uniform in composition and function. Here, we
show that nutrient limitation-induced stress in E. coli changes the relative expression of …

Introduction During protein synthesis, the guanosine triphosphatase (GTPase) elongation
factor G (EF-G) promotes translocation of messenger RNA (mRNA) and transfer RNA (tRNA) …

Knowing the structure of conserved structural RNAs is important to elucidate their function
and mechanism of action. However, predicting a conserved RNA structure remains …

During protein synthesis, the ribosome translates nucleotide triplets in single-stranded
mRNA into polypeptide sequences. Strong downstream mRNA secondary structures, which …

Directional translocation of the ribosome through the mRNA open reading frame is a critical
determinant of translational fidelity. This process entails a complex interplay of large-scale …