Cutaneous squamous cell carcinoma: from biology to therapy

R Corchado-Cobos, N García-Sancha… - International journal of …, 2020 - mdpi.com
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans
and its incidence continues to rise. Although CSCC usually display a benign clinical …

Vismodegib: a review in advanced basal cell carcinoma

JE Frampton, N Basset-Séguin - Drugs, 2018 - Springer
Vismodegib (Erivedge®) is the first-in-class, oral small molecule inhibitor of the Hedgehog
(Hh) pathway, abnormal activation of which is associated with basal cell carcinoma (BCC) …

Hedgehog pathway inhibition for the treatment of basal cell carcinoma

R Gutzmer, JA Solomon - Targeted Oncology, 2019 - Springer
Globally, basal cell carcinoma is the most commonly diagnosed cancer. While most cases
are amenable to surgery, treatment options for advanced basal cell carcinoma, including …

Targeting the Hedgehog pathway in cancer: current evidence and future perspectives

D Girardi, A Barrichello, G Fernandes, A Pereira - Cells, 2019 - mdpi.com
The Hedgehog pathway (HhP) plays an important role in normal embryonic development
and its abnormal function has been linked to a variety of neoplasms. Recently, the complex …

Sonic hedgehog pathway inhibition in the treatment of advanced basal cell carcinoma

E Leavitt, G Lask, S Martin - Current treatment options in oncology, 2019 - Springer
Opinion statement Advanced basal cell carcinoma (BCC) represents a small proportion of
BCCs that are not amenable to standard therapies due to lack of efficacy, high recurrence …

Basosquamous Carcinoma: Comprehensive Clinical and Histopathological Aspects, Novel Imaging Tools, and Therapeutic Approaches

G Murgia, N Denaro, F Boggio, G Nazzaro, V Benzecry… - Cells, 2023 - mdpi.com
Basosquamous carcinoma (BSC), an uncommon and aggressive nonmelanoma skin cancer
exhibiting characteristics ranging from basal cell carcinoma (BCC) to squamous cell …

Evolving role of systemic therapies in non-melanoma skin cancer

C Conforti, P Corneli, C Harwood, I Zalaudek - Clinical Oncology, 2019 - Elsevier
Keratinocyte cancers–basal and cutaneous squamous cell carcinoma (BCC, cSCC)–are the
most common forms of non-melanoma skin cancer (NMSC) and there has been a significant …

Ocular preservation with neoadjuvant vismodegib in patients with locally advanced periocular basal cell carcinoma

O Sagiv, P Nagarajan, R Ferrarotto, TJ Kandl… - British Journal of …, 2019 - bjo.bmj.com
Background/Aims Locally advanced (T4 per American Joint Committee on Cancer (AJCC)
8th edition) periocular basal cell carcinoma (BCC) can lead to loss of the eye. We report the …

Aging and the treatment of basal cell carcinoma

S Sreekantaswamy, J Endo, A Chen, D Butler… - Clinics in …, 2019 - Elsevier
Basal cell carcinoma (BCC) is the most commonly diagnosed type of skin cancer. BCCs are
especially prevalent in the elderly population, given their association with cumulative sun …

Basosquamous carcinoma: a commentary

C Fotiadou, Z Apalla, E Lazaridou - Cancers, 2021 - mdpi.com
Simple Summary Basosquamous carcinoma is a rare, aggressive non-melanoma skin
cancer with features that lie between those of basal cell carcinoma and squamous cell …